Base-Catalysis of Imino Proton Exchange in DNA: Effects of Catalyst upon DNA Structure and Dynamics
โ Scribed by Folta-Stogniew, Ewa; Russu, Irina M.
- Book ID
- 125990990
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 444 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0006-2960
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๐ SIMILAR VOLUMES
## Abstract Backbone amide proton exchange rates in the DNAโbinding domain of GAL4 have been determined using ^1^Hโ^15^N heteronuclear correlation NMR spectroscopy. Three forms of the protein were studied โ the native Znโcontaining protein, the Cdโsubstituted protein, and a ZnโGAL4/DNA complex. Exc
Modified self-consistent phonon theory when applied to the DNA double helix indicates the existence of fairly long-lived states in which single interbase H bonds are disrupted. One can then postulate a number of situations in which particular disrupted H bonds can enhance particular proton exchange.