Basal keratinocyte tetrasomy in low-grade squamous intra-epithelial lesions of the cervix is restricted to high and intermediate risk HPV infection but is not type-specific

p53 codon 72 ARG/PRO polymorphism is not

p53 codon 72 ARG/PRO polymorphism is not related to HPV type or lesion grade in low- and high-grade squamous intra-epithelial lesions and invasive squamous carcinoma of the cervix

✍ Athina Giannoudis; David A. Graham; Shirley A. Southern; C. Simon Herrington 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 441 KB 👁 1 views

A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. However, the relevance of this polymorphism to naturally occ