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✦   LIBER   ✦

Basal ganglia physiology and deep brain stimulation

✍ Scribed by Andres M. Lozano; Brian J. Snyder; Clement Hamani; William D. Hutchison; Jonathan O. Dostrovsky

Book ID
102508948
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
133 KB
Volume
25
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Despite improvements in anatomic imaging of the basal ganglia, microelectrode recording is still an invaluable tool in locating appropriate targets for neurosurgical intervention. These recording also provide an unparalleled opportunity to study the pathophysiological aspects of diseases. This article reviews the principles of microelectrode recording in functional neurosurgery and discusses the pathologic neurophysiologic findings commonly encountered. It also highlights some of the potential mechanisms of action of both dopaminergic drugs and deep brain stimulation. In addition we review the recent work on pedunculopontine nucleus neurophysiology and trials of deep brain stimulation in that region for gait disturbances in Parkinson's disease. Β© 2010 Movement Disorder Society

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