Urocanic acid (UCA) is a major chromophore for ultraviolet (UV) radiation in the skin. On UV exposure, the naturally occurring trans-isomer converts to the cis-isomer in a dose-dependent manner. Accumulating evidence indicates that cis-UCA acts as an initiator of the UV-induced suppression of certai
Basal cell carcinoma in young patients after irradiation for childhood malignancy
β Scribed by Dinehart, Scott M. ;Anthony, John L. ;Pollack, Sheldon V.
- Book ID
- 102521602
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 307 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0098-1532
No coin nor oath required. For personal study only.
β¦ Synopsis
Three patients underwent cranial irradiation as part of treatment for childhood malignancy. Two of these patients had acute lymphocytic leukemia and one had an astrocytoma. All had longlasting remissions from their childhood malignancy but 8-15 years later developed a basal cell carcinoma of the scalp within previous radiation portals. The basal cell carcinomas were all treated successfully using Mohs micrographic surgery. Follow-up of patients receiving irradiation for childhood malignancy should include periodic cutaneous examinations of previously irradiated sites.
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