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BARD1, a possible biomarker for breast and ovarian cancer

✍ Scribed by Irmgard Irminger-Finger

Book ID
113962311
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
497 KB
Volume
117
Category
Article
ISSN
0090-8258

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## Abstract Mutations in tumor‐suppressor gene __BARD1__ have been found in inherited and spontaneous breast, ovarian and uterine cancers. __BARD1__ plays a critical role in DNA repair and ubiquitination as binding partner of __BRCA1,__ with which it colocalizes to nuclear dots. Independently of __

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## Abstract Hereditary breast cancers (BCs) are incompletely explained by __BRCA__ genes abnormalities, as ∼70% of them are not associated with known genetic alterations. Array‐based comparative genomic hybridization (aCGH) of tumors provides an opportunity for identifying new BC susceptibility gen