Band Keratopathy in MRL/1 and MRL/n Mice

✍ Scribed by Robert W. Hoffman; H. Yang Kell; Kim S. Waggie; James B. Durham; Julia R. Burge; Sara Ellen Walker

• Book ID: 102752740
• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 773 KB
• Volume: 26
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780260511

✦ Synopsis

To define ocular abnormalities in mice with autoimmune disease, we performed biomicroscopic examinations and examined ocular tissue in MRL/I, MRL/n, NZB, NZB/NZW, and Palmerston North mice. Results were compared with MRLIMp-lprllpr, C57BL/6J-lpr/lpr, and normal control strains. Eightyseven percent of MRL/I and MRL/n mice had typical band keratopathy; this was confirmed by histologic examination. Posterior uveitis was found in 35% of adult MRLA mice. MRL substrains are potentially important models of ocular disease.

Inflammatory rheumatic disease such as systemic lupus erythematosus, periarteritis nodosa, rheumatoid arthritis, and juvenile arthritis may result in eye disease which leads to significant morbidity and blindness (1). Because eyes from few patients with rheumatic diseases are available for detailed examina-From the Veterans Administration Medical Center, Columbia, MO and the University of Missouri-Columbia.