This study examines the issue of false positives in genomic scans for detecting complex trait loci using sibpair linkage methods and investigates the trade-off between the rate of false positives and the rate of false negatives. It highlights the tremendous cost in terms of power brought about by an
Balancing false positives and false negatives for the detection of differential expression in malignancies
โ Scribed by De Smet, F; Moreau, Y; Engelen, K; Timmerman, D; Vergote, I; De Moor, B
- Book ID
- 109998258
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 119 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0007-0920
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
BCR-ABL fluorescence in situ hybridization has a useful role to play in experimental and clinical investigations of chronic myeloid leukaemia. However, the interpretation of results is complicated by variability in the false positive rate (FPR) and false negative rate (FNR). We therefore examined th
The t(9;22) translocation resulting in the fusion of BCR and ABL genes is pathognomonic in chronic myeloid leukemia (CML) and may be investigated at the molecular level using fluorescence in situ hybridization (FISH). Two-color BCR-ABL probes visualizing one fusion signal (1F FISH) have high false p