Blockade of CTLA-4 enhances allergic sen
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PeterβW. Hellings; Peter Vandenberghe; Ahmad Kasran; Lieve Coorevits; Lutgart Ov
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Article
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2002
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John Wiley and Sons
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English
β 383 KB
CTLA-4 (CD152) expression is restricted to subsets of activated T lymphocytes and shares homology with CD28. CTLA-4 and CD28 molecules both bind to B7 molecules on antigenpresenting cells. Whereas CD28-B7 interaction enhances T cell activation, cytokine production and survival, CTLA-4 signaling down