Bacteriorhodopsin α-helices in lipid settings: Insights for structure prediction
✍ Scribed by Thomas B. Woolf
- Book ID
- 101252033
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 352 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0020-7608
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✦ Synopsis
The two-stage model of membrane protein folding predicts that isolated transmembrane ␣-helices form stably in the bilayer before coming together to form the fully functional protein. Insight into the molecular implications of this model are possible with detailed molecular dynamics calculations. Thirty molecular dynamics simulations of both individual and pairs of ␣-helices from bacteriorhodopsin were calculated with the CHARMm program. This data base will continue to grow and expand. Already, differences between identical helices in different media and different helices in the same media have been found. The current results are summarized in this contribution. ᮊ 1998