The influence of the 5-methyl group in b
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M. Groesbeek; E. F. J. de Vries; J. A. Berden; J. Lugtenburg
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Article
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2010
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Elsevier Science
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English
⚖ 594 KB
## Abstract All‐__E__‐5‐bromo‐5‐demethylretinal was prepared in 6% yield starting from 4,4‐dimethyl‐2‐cyclohexenone via 2‐bromo‐6,6‐dimethyl‐1‐cyclohexenecarboxaldehyde. The crucial step in the preparation of the intermediate is a 2,3 Wittig rearrangement. 5‐Bromo‐5‐demethylbacteriorhodopsin is eas