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Bactericidal effects of antimicrobial agents on epithelial cell-associatedPseudomonas aeruginosa

✍ Scribed by Hirakata, Yoichi; Yano, Hisakazu; Arai, Kazuaki; Kitagawa, Miho; Hatta, Masumitsu; Kunishima, Hiroyuki; Kaku, Mitsuo

Book ID
113057742
Publisher
Springer
Year
2012
Tongue
English
Weight
286 KB
Volume
18
Category
Article
ISSN
1341-321X

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## Abstract The cell‐penetrating peptide Tat (48–60) (GRKKRRQRRRPPQ) derived from HIV‐1 Tat protein showed potent antibacterial activity (MIC: 2–8 Β΅M). To investigate the effect of dimerization of Tat (48–60) analog, [Tat(W): GRKKRRQRRRPWQ‐NH~2~], on antimicrobial activity and mechanism of bacteric