Bacterial Pathogenesis: Methods and Protocols

✍ Scribed by Michael A. Apicella (auth.), Frank R. DeLeo, Michael Otto (eds.)

• Publisher: Humana Press
• Year: 2008
• Tongue: English
• Leaves: 313
• Series: Methods in Molecular Biology™ 431
• Edition: 1
• Category: Library

✦ Synopsis

Bacterial infections affect world health today as a leading cause of morbidity and mortality. Pathogenic bacteria routinely command a broad spectrum of niches in the human host, making an understanding of pathogenesis mechanisms crucial to the development of prophylactics and treatment for bacterial diseases. A variety of in vitro methods, in vivo animal model systems and cutting-edge genomics assays have arisen in the effort to study bacterial pathogenesis and identify potential therapeutic targets. In Bacterial Pathogenesis, in-depth methods and state-of-the-art protocols are presented for investigating specific mechanisms of pathogenesis for a wide range of bacteria. This invaluable collection includes protocols to study host-pathogen interactions, animal models of infection, and novel approaches to identifying therapeutic targets designed to control infections. Up-to-date molecular typing methods for Staphylococcus aureus and a new model of streptococcal pharyngitis in non-human primates are also included. Bacterial Pathogenesis will prove an invaluable collection for microbiologists, immunologists, cell biologists and infectious disease clinicians - and indispensable to all science researchers interested in studying pathogenic bacteria and related disease processes.

✦ Table of Contents

Front Matter....Pages i-xv
Front Matter....Pages 1-1
Front Matter....Pages 3-13
Front Matter....Pages 15-24
Front Matter....Pages 25-45
Back Matter....Pages 47-53
....Pages 55-68

✦ Subjects

Microbiology; Immunology; Cell Biology