Bacterial mutagenicity of methylated benz[a]anthracenes: great differences in metabolic activation and lack of correlation with carcinogenicity

Lack of correlation between DNA-methylat

Lack of correlation between DNA-methylating activity and appearance of the immunogenic phenotype in clones of a murine lymphoma treated with mutagens

✍ Patrizia Fuschiotti; Maria C. Fioretti; Luigina Romani; Paolo Puccetti 📂 Article 📅 1989 🏛 Springer-Verlag 🌐 English ⚖ 549 KB

The relationship between induction of novel immunogenicity by xenogenizing chemicals and DNA-methylating activity in murine tumors was investigated at the clonal level in L1210Ha cells treated with 5-azacytidine, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or 1-(p-chlorophenyl)-3,3-dimethyltriazene