𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Bacterial membrane lipids in the action of antimicrobial agents

✍ Scribed by Richard M. Epand; Raquel F. Epand

Book ID
105359947
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
186 KB
Volume
17
Category
Article
ISSN
1075-2617

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Many antimicrobial agents that target bacteria are cationic and can interact with the anionic lipid components that are exposed on the bacterial membrane. Bacteria vary widely in the nature of the major lipid components that are in the cell membrane. Those bacteria with both anionic as well as zwitterionic or neutral lipids can be induced to form domains in the presence of antimicrobial peptides possessing several cationic charges. This segregation of anionic and zwitterionic lipids into domains can result in the arrest of cell growth or in cell death. Such agents are generally more toxic to Gram‐negative bacteria, than to Gram‐positive ones. These findings emphasize the importance of the lipid composition of bacterial membranes in determining the susceptibility of the organism to the action of certain antimicrobial agents. Copyright Β© 2010 European Peptide Society and John Wiley & Sons, Ltd.

πŸ“œ SIMILAR VOLUMES

New antimicrobial agents for the treatme
New antimicrobial agents for the treatment of bacterial infections in cancer patients
✍ Kenneth V. I. Rolston πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 126 KB

## Abstract Patients with cancer develop serious bacterial infections often, especially during periods of severe and prolonged neutropenia. Antibiotic usage for the prevention and treatment of bacterial infections in these high‐risk patients leads to selection pressures resulting in the emergence a