Bacterial Genomes and Infectious Diseases

✍ Scribed by Voon Loong Chan PhD (auth.), Voon L. Chan PhD, Philip M. Sherman MD, FRCPC, Billy Bourke MD, FRCPI (eds.)

• Publisher: Humana Press
• Year: 2006
• Tongue: English
• Leaves: 275
• Edition: 1
• Category: Library

✦ Synopsis

The emergence and reemergence of infectious diseases, an increasing rate of antibiotic-resistant variants of pathogens, and the threat of bioterrorism underscore the importance of bacterial genomes and infectious diseases. Bacterial Genomes and Infectious Diseases presents major findings about bacterial genomes and their impact on strategy and approach for investigating mechanisms of pathogenesis of infectious diseases. This book imparts fundamental knowledge on the structure, organization, and evolution of bacterial genomes. The value and power of comparative genomics and proteomics, bioinformatics, microarrays, and knockout animal models in analyzing genomes, bacteria-host interactions and disease are demonstrated. Also discussed are the genomes of virulent and nonvirulent strains and species, origin and evolution of pathogens, different models of bacteria-host interactions, and diseases mechanisms.

✦ Table of Contents

Front Matter....Pages i-xiii
Microbial Genomes....Pages 1-19
Evolution and Origin of Virulence Isolates....Pages 21-30
Genomic Approach to Understanding Infectious Disease Mechanisms....Pages 31-39
Knockout and Disease Models in Toll-Like Receptor-Mediated Immunity....Pages 41-61
Campylobacter....Pages 63-90
Genomics of Helicobacter Species....Pages 91-107
The Organization of Leptospira at a Genomic Level....Pages 109-123
Listeria monocytogenes....Pages 125-149
Mycobacterial Genomes....Pages 151-174
Mycoplasma....Pages 175-190
Genome Comparisons of Diverse Staphylococcus aureus Strains....Pages 191-212
Type III Secretion Systems in Yersinia pestis and Yersinia pseudotuberculosis ....Pages 213-226
Genomics and the Evolution of Pathogenic Vibrio cholerae ....Pages 227-254
Future Directions of Infectious Disease Research....Pages 255-264
Back Matter....Pages 265-270

✦ Subjects

Infectious Diseases; Microbiology; Immunology; Microbial Genetics and Genomics