𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Bactenecin, a leukocytic antimicrobial peptide, is cytotoxic to neuronal and glial cells

✍ Scribed by S. W. Radermacher; V. M. Schoop; Dr. H. J. Schluesener

Book ID
102909639
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
721 KB
Volume
36
Category
Article
ISSN
0360-4012

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✦ Synopsis

Small antimicrobial peptides are abundantly produced by leukocytes. These peptides are active against a broad range of pathogens, notably bacteria, fungi, and enveloped viruses, but hardly anything is known about their physiological and pathophysiological relevance.

We observed that bactenecin, a dodecapeptide, is strongly cytotoxic to rat embryonic neurons, fetal rat astrocytes and human glioblastoma cells. This neurotoxicity is unique to bactenecin, as a panel of antibacterial peptides from vertebrates and invertebrates, like defensins, corticostatin, indolicidin, cecropin P1, tachyplesin I, the magainins, or apidaecins did not impair neuronal viability.

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