Baclofen-induced generalized nonconvulsive status epilepticus
โ Scribed by Rochelle Zak; Gail Solomon; Frank Petito; Douglas Labar
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 212 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
โฆ Synopsis
Baclofen has been reported to produce a "metabolic" type encephalopathy with periodic generalized electroencephalographic (EEG) sharp waves in 3 previous cases 11, 21. We recently cared for a similar patient, whose mental status and EEG normalized after treatment with diazepam and phenytoin. Thus, we believe all 4 cases had generalized nonconvul-Elrrtroencephalogram showing generalized periodic sharp waves occurring with a repetition rate of 1 to 2 Hz. associated with enrephalopathy. Electrode nomenclature and placement follozc~ed the International 10-20 System. Siherlsilver chloride electrodes were used.
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Hospitalized patients with sepsis or severe nosocomial infections are frequently treated empirically with broadspectrum antibiotics. Cefepime hydrochloride, a fourth-generation cephalosporin, is a common antibiotic of first choice. Its proconvulsant properties are well described in the literature, 1