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BACE1gene promoter is differentially regulated

✍ Scribed by Debomoy K. Lahiri; Bryan Maloney; Yuan-Wen Ge

Book ID
111639911
Publisher
Humana Press Inc
Year
2006
Tongue
English
Weight
546 KB
Volume
28
Category
Article
ISSN
0895-8696

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## Abstract The β‐amyloid peptides derived by proteolytic cleavage from the amyloid precursor protein (APP) play a major role in the pathogenesis of Alzheimer's disease (AD) by forming aggregated, fibrillary complexes that have been shown to be neurotoxic. The β‐site APP‐cleaving enzyme (BACE1) has