BACE1 is the major β-secretase for generation of Aβ peptides by neurons
✍ Scribed by Cai, Huaibin; Wang, Yanshu; McCarthy, Diane; Wen, Hongjin; Borchelt, David R.; Price, Donald L.; Wong, Philip C.
- Book ID
- 109829970
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 778 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1097-6256
- DOI
- 10.1038/85064
No coin nor oath required. For personal study only.
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## Abstract β‐Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is a membrane‐bound protease that is essential for the production of β‐amyloid protein (Aβ). Given the crucial role of Aβ accumulation in Alzheimer's disease (AD), inhibition of BACE1 activity may represent a feasible ther