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B556 CXCR7 Regulates SDF-1 Induced, Adhesion, Homing, and Signaling in Multiple Myeloma

✍ Scribed by Burwick, N; Roccaro, AM; Moreau, AS; Jia, X; Leleu, X; Runnels, J; Ngo, HT; Melhem, MR; Azab, F; Azab, AK; Lin, CP; Anderson, KC; Ghobrial, IM

Book ID: 118629542
Publisher: CIG Media Group, LP.
Year: 2009
Tongue: English
Weight: 93 KB
Volume: 9
Category: Article
ISSN: 1557-9190
DOI: 10.1016/s1557-9190(11)70770-3

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The chemokine stromal-derived factor-1alpha (SDF-1alpha) and its receptor CXCR4 are critically involved in directional migration and homing of plasma cells in multiple myeloma. Here, we show that the expression of SDF-1alpha and CXCR4 was significantly down-regulated in patients treated with thalido