𝔖 Bobbio Scriptorium
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B358 SF1126, A Novel PI3K Inhibitor Results in Downstream Inhibition of the PI3K Axis and Displays Sequen

✍ Scribed by David, E; Lonial, S; Barwick, B; Peng, X; Kaufman, J; Garlich, J


Book ID
118629488
Publisher
CIG Media Group, LP.
Year
2009
Tongue
English
Weight
96 KB
Volume
9
Category
Article
ISSN
1557-9190

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## Abstract Gemcitabine has limited clinical benefits for pancreatic ductal adenocarcinoma (PDAC). The phosphatidylinositol‐3‐kinase (PI3K)/AKT and mammalian target of rapamycin (mTOR) signaling pathways are frequently dysregulated in PDAC. We investigated the effects of NVP‐BEZ235, a novel dual PI