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B331 Tyrosine Kinase Inhibition in MM? Efficacy of the Combination of Dasatinib/Bortezomib/Dexamethasone

✍ Scribed by de Queiroz Crusoe, E; Ocio, EM; Maiso, P; San-Segundo, L; Fernández, D; Garayoa, M; Pandiella, A; San Miguel, J


Book ID
118629481
Publisher
CIG Media Group, LP.
Year
2009
Tongue
English
Weight
96 KB
Volume
9
Category
Article
ISSN
1557-9190

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The tyrosine kinase inhibitor dasatinib
✍ Kate Vandyke; Andrea L Dewar; Peter Diamond; Stephen Fitter; Christopher G Schul 📂 Article 📅 2010 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 423 KB

## Abstract Dasatinib is a potent tyrosine kinase inhibitor that is used to treat chronic myeloid leukemia in patients resistant or intolerant to imatinib mesylate. While designed to inhibit Abl and Src kinases, dasatinib shows multitarget effects, including inhibition of the macrophage colony‐stim