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B-cell epitopes on the hepatitis C virus nucleocapsid protein determined by human monospecific antibodies

✍ Scribed by Toshitaka Akatsuka; Mickhail Donets; Luca Scaglione; Wei-Mei Ching; J. Wai-Kuo Shih; Adrian M. Di Bisceglie; Stephen M. Feinstone


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
948 KB
Volume
18
Category
Article
ISSN
0270-9139

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✦ Synopsis


Four monospecific antibodies against the hepatitis C indicates that HCV is distantly related to the Fluvirus nucleocapsid protein, which was expressed by uiviridue family that includes flaviviruses and pestivirecombinant baculovirusl were obtained by EP-ruses (7-10). As demonstrated in flaviviruses (11) and stein-Barr virus transformation of B cells from three supported by in uitro translations of cloned HCV patients with chronic hepatitis C virus infection. One sequences (121, the HCV polyprotein is processed into


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## Abstract A rare collection of serum samples from patients with hepatitis C virus (HCV) infection followed up from the onset of clinical symptoms was acquired. RNA corresponding to the hypervariable region 1 (HVR1) of E2 protein of HCV isolated from nine patients was reverse‐transcribed, amplifie