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B-cell development: BCL-6 recruits new team member

โœ Scribed by Minton, Kirsty


Book ID
109954748
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
193 KB
Volume
4
Category
Article
ISSN
1474-1741

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โœ Huifeng Niu ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 103 KB

BCL-6 is an important regulator of the immune system. It is required for GC formation and T cell dependent antibody responses. Mice deficient in BCL-6 fail to form GC and mount reduced levels of T cell-dependent antibody responses. BCL-6 (-/-) mice, in addition, develop a massive inflammatory respon