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B Cell Affinity Discrimination Requires Kinetic Proofreading

✍ Scribed by Tsourkas, Philippos; Raychaudhuri, Subhadip


Book ID
122978793
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
31 KB
Volume
98
Category
Article
ISSN
0006-3495

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## Abstract In the present study we used a human follicular lymphoma cell line, HF1A3, as an __in vitro__ model for the antigen‐driven selection process in germinal centers. Apoptosis can be induced in HF1A3 cells by B cell receptor (BCR) stimulation, but the molecular mechanisms and kinetics of th