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B- and T-cell Development Both Involve Activity of the Unfolded Protein Response Pathway

✍ Scribed by Brunsing, R.; Omori, S. A.; Weber, F.; Bicknell, A.; Friend, L.; Rickert, R.; Niwa, M.


Book ID
111886714
Publisher
The American Society for Biochemistry and Molecular Biology
Year
2008
Tongue
English
Weight
461 KB
Volume
283
Category
Article
ISSN
0021-9258

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Estrogen (E2)-induced immunomodulation involves dual effects on antigen-presenting cells (APC) and CD4(+)CD25(+) regulatory T cells (Treg) but not a direct effect on effector T cells. In this report, we further investigated the effects of E2 on APC and Treg function. We found that E2 treatment in vi