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Aβ(31–35) peptide induce apoptosis in PC 12 cells: Contrast with Aβ(25–35) peptide and examination of underlying mechanisms

✍ Scribed by Francesco Misiti; Beatrice Sampaolese; Michela Pezzotti; Stefano Marini; Massimo Coletta; Lia Ceccarelli; Bruno Giardina; Maria Elisabetta Clementi


Book ID
116764628
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
308 KB
Volume
46
Category
Article
ISSN
0197-0186

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We previously found that the atypical antipsychotic drugs (APDs) clozapine, olanzapine, quetiapine, and risperidone reduce PC12 cell death induced by hydrogen peroxide, N-methyl-4-phenylpyridinium ion, or beta-amyloid peptide (Abeta(25-35)). Such neurotoxic substances have in common the capability o