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Azoxymethane-induced fulminant hepatic failure (FHF) in mice: Characterization of a new animal model

✍ Scribed by Matkowskyj, KA; Marrero, JA; Carroll, RE; Green, R; Benya, RV

Book ID
122093186
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
172 KB
Volume
114
Category
Article
ISSN
0016-5085

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We have established an improved model of fulminant hepatic failure in dogs. Buthionine sulfoximine is used to inactivate glutathione synthesis, and small increments of acetaminophen are given intravenously to maintain the plasma level at approximately 200 pg/ml for 20 hr. This regimen produces sever