Azonia derivatives of the γ-carboline system. A new class of DNA intercalators

✍ Scribed by Andrés Molina; Juan J. Vaquero; JoséL. García-Navio; Julio Alvarez-Builla; María M. Rodrigo; Obis Castaño; JoséL. de Andres

• Book ID: 104364585
• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 238 KB
• Volume: 6
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(96)00243-0

✦ Synopsis

1-Methyl-y-carboline derivatives were transformed into the corresponding N-aminoazinium salts, which were condensed with 1,2-dicarbonyl compounds (Westphal reaction) to afford azonia derivatives with a bridgehead quaternary nitrogen atom. Some of them show DNA intercalating properties.