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Azobenzene as Photoresponsive Conformational Switch in Cyclic Peptides
β Scribed by C. Renner; U. Kusebauch; M. Loeweneck; A. G. Milbradt; L. Moroder
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 8 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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and Kates119] based on the deuterium isotopic perturbation effect. An additional factor that supports this conclusion can be found by analyzing further the CH stretching region. In the hypothetical classical 2-norbornyl cation, the hyperconjugative interaction of the C ( 3 j H bonds with the formall
The search for photoresponsive conformational transitions accompanied by changes in physicochemical and biological properties led us to the design of small cyclic peptides containing azobenzene moieties in the backbone. For this purpose, (4-aminomethyl)phenylazobenzoic acid (H-AMPB-OH) and (4-amino)
Scheme 1. Structures of synthetic cyclic peptides related to the active site of E. coli thioredoxin reductase and containing 4-(4-