Azathioprine and mesalazine-induced effects on the mucosal flora in patients with IBD colitis

✍ Scribed by Alexander Swidsinski; Vera Loening-Baucke; Stig Bengmark; Herbert Lochs; Yvonne Dörffel

• Book ID: 102263158
• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 205 KB
• Volume: 13
• Category: Article
• ISSN: 1078-0998
• DOI: 10.1002/ibd.20003

✦ Synopsis

Background:

The impact of azathioprine and 5-aminosalicylic acid (5-ASA) on the innate immunity and mucosal flora is unknown. The study investigated the influence of IBD treatment on the concentrations and spatial organization of mucosal bacteria using fluorescence in situ hybridization with 16s r-RNA targeting probes.

Methods:

We prospectively investigated colonoscopic biopsies from five groups of 20 subjects each: patients with ulcerative or indeterminate colitis treated with azathioprine (group 1), azathioprine and 5-ASA (group 2), 5-ASA (group 3), untreated IBD (group 4), and healthy controls.