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Azabicyclo[3.3.0]octanes and 6-hydroxytetrahydroquinolines from intramolecular reactions of alkenyl(amino)carbene complexes with alkynes.

✍ Scribed by Annette Rahm; William D. Wulff


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
364 KB
Volume
36
Category
Article
ISSN
0040-4039

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Reactions of 4-Oxoalkanoic Acids, 4. Syn
✍ Wedler, Christine ;Schick, Hans ;Scharfenberg-Pfeiffer, Doris ;Reck, Günter 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 432 KB

## Abstract Ethyl 4‐oxoalkanoates 1 react at ambient temperature in dry methanol in the presence of molecular sieve 3 Å in almost quantitative yield with 3‐aminopropanol and 2‐aminoethanol to form the bicyclic lactams __rac__‐2 and __rac__‐3, respectively. Surprisingly, the (±)‐5‐alkyl‐4‐oxa‐1‐azab