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Azabicyclo[3.1.0]hexane-1-carbohydrazides as Potent and Selective GHSR1a Ligands Presenting a Specific in vivo Behavior

✍ Scribed by Dr. Fabio Maria Sabbatini; Dr. Sergio Melotto; Dr. Giovanni Bernasconi; Dr. Steve M. Bromidge; Dr. Lucilla D'Adamo; Dr. Marilisa Rinaldi; Dr. Chiara Savoia; Dr. Claudia Mundi; Dr. Carla Di Francesco; Dr. Laura Zonzini; Dr. Vivian J. A. Costantini; Dr. Benedetta Perini; Dr. Enzo Valerio; Dr. Alfonso Pozzan; Dr. Elisabetta Perdonà; Dr. Filippo Visentini; Dr. Mauro Corsi; Dr. Romano Di Fabio


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
263 KB
Volume
6
Category
Article
ISSN
1860-7179

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Triazolyl Azabicyclo[3.1.0]hexanes: a Cl
✍ Giorgio Bonanomi; Simone Braggio; Anna Maria Capelli; Anna Checchia; Romano Di F 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 613 KB

## Abstract __Herein we report a detailed description of the structure–activity relationships for a novel series of “C‐linked” 1,2,4‐triazolylazabicyclo[3.1.0]hexanes. These derivatives are endowed with very high in vitro affinity and selectivity for the dopamine D~3~ receptor. An optimization with