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Azabicyclo chemistry. IV. New route to 2-azabicyclo[3.3.1]nonanes containing a functionalized carbocyclic ring

✍ Scribed by Mokotoff, Michael; Cavestri, Richard C.


Book ID
126180971
Publisher
American Chemical Society
Year
1974
Tongue
English
Weight
451 KB
Volume
39
Category
Article
ISSN
0022-3263

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Cyclization of 1-(carbamoyl)dichlorometh
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The synthesis of 2-azabicyclo[3.3.1]nonanes using a radical cyclization process as the piperidine ring-forming step is described. The reaction involves 1-(carbamoyl)dichloromethyl radicals which react inlramolecularly with simple or activated alkenas, such as enol acetates or silyl enol ethers.