Aza-Bicyclic Amino Acid Sulfonamides as α4β1/α4β7 Integrin Antagonists.
✍ Scribed by Alexey B. Dyatkin; et al. et al.
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 142 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
For Abstract see ChemInform Abstract in Full Text.
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The tuning of protein ± protein interactions by small nonpeptidic molecules remains one of the great challenges in medicinal chemistry. Although already proposed in 1980 by Farmer, [1] only a few successful examples on the synthesis of peptidomimetics based on rigid scaffolds such as cyclohexane and
The tuning of protein ± protein interactions by small nonpeptidic molecules remains one of the great challenges in medicinal chemistry. Although already proposed in 1980 by Farmer, [1] only a few successful examples on the synthesis of peptidomimetics based on rigid scaffolds such as cyclohexane and