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aza-Annulation of β-aminovinyl trifluoromethyl ketones with acryloyl chloride: an efficient synthesis of 5-(trifluoroacetyl)-3,4-dihydro-2(1H)-pyridinones

✍ Scribed by Lyutenko, Nataliya V.; Gerus, Igor I.


Book ID
120389482
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
348 KB
Volume
54
Category
Article
ISSN
0040-4039

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✍ Aihua Wang; Yan Zhang; Songfeng Lu; William V. Murray; Gee-Hong Kuo 📂 Article 📅 2010 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 140 KB

## Abstract magnified image An efficient and scalable synthesis of the potent CETP inhibitor, (2__R__,α__S__)‐3,4‐dihydro‐2‐[3‐(1,1,2,2‐tetrafluoroethoxy)phenyl]‐5‐[3‐(trifluoromethoxy)phenyl]‐α‐(trifluoromethyl)‐1(2__H__)‐quinolineethanol 1, is described. One of the important intermediates, tetrah