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Axonal outgrowth and neuronal apoptosis in cultured adult mouse dorsal root ganglion preparations: effects of neurotrophins, of inhibition of neurotrophin actions and of prior axotomy

✍ Scribed by A Edström; P.A.R Ekström; D Tonge

Book ID: 116129502
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 611 KB
Volume: 75
Category: Article
ISSN: 0306-4522
DOI: 10.1016/0306-4522(96)00324-7

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## Abstract PD98059 blocks mitogen‐activated protein kinase (MAPK) by inhibiting its activator, MAP kinase kinase (MEK). We have previously found that PD98059 only transiently inhibits spontaneous axonal outgrowth from adult mouse dorsal root ganglia (DRG) explants, whereas it causes sustained inhi