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Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system

✍ Scribed by Kanaan, Nicholas M.; Pigino, Gustavo F.; Brady, Scott T.; Lazarov, Orly; Binder, Lester I.; Morfini, Gerardo A.

Book ID: 120407605
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 663 KB
Volume: 246
Category: Article
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2012.06.003

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Axonal pathology is a prevalent feature of Alzheimer's disease (AD) and is thought to occur predominantly due to the accumulation of amyloid beta (Aβ). However, it remains unclear whether therapeutics geared toward reducing Aβ improves axonal deficits. We have previously used Manganese Enhanced MRI