Using axonal tracers, we characterized the neurons projecting from the brain to the spinal cord as well as the terminal fields of ascending spinal projections in the brain of adult zebrafish with unlesioned or transected spinal cords. Twenty distinct brain nuclei were found to project to the spinal
Axon sprouting in adult mouse spinal cord after motor cortex stroke
β Scribed by Christine M. LaPash Daniels; Kathryn L. Ayers; Amanda M. Finley; Joseph P. Culver; Mark P. Goldberg
- Book ID
- 116771008
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 682 KB
- Volume
- 450
- Category
- Article
- ISSN
- 0304-3940
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## Abstract We reported recently that overexpression of neurotrophinβ3 (NTβ3) by motoneurons in the spinal cord of rats will induce sprouting of corticospinal tract (CST) axons (Zhou et al. [2003] J. Neurosci. 23:1424β1431). We now report that overexpression of brainβderived neurotrophic factor (BD
We describe an experimental model to study regeneration of lesioned corticospinal tract (CST) fibers in the adult rat spinal cord. After transection of all CST fibers at mid-thoracic level the gap is grafted with a sterile, cell-free collagen matrix. Two methods of collagen-application are used: 1)