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Axon-Schwann cell interactions regulate the expression of fibroblast growth factor-5 (FGF-5)

✍ Scribed by Marina Scarlato; Theodore Xu; Peter Bannerman; Jacqueline Beesley; Usha R. Reddy; Abdolmohammad Rostami; Steven S. Scherer; David Pleasure

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
159 KB
Volume
66
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

We screened for genes whose expression is significantly up‐ or downregulated during Wallerian degeneration in adult rat sciatic nerve with cDNA arrays. Fibroblast growth factor‐5 (FGF‐5) mRNA seemed to be induced. This was confirmed by northern blotting and in situ hybridization, as well as Western blotting for FGF‐5 in axotomized nerve. Axon‐Schwann cell interactions decreased the steady‐state level of FGF‐5 mRNA in regenerating sciatic nerves, and forskolin diminished its expression in cultured Schwann cells. We conclude that denervated Schwann cells synthesize FGF‐5, which is a secreted, neuronotrophic member of the FGF family. J. Neurosci. Res. 66:16–22, 2001. © 2001 Wiley‐Liss, Inc.

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