Axon Function Persists During Anoxia in Mammalian White Matter
β Scribed by Tekk??k, Selva Baltan; Brown, Angus M.; Ransom, Bruce R.
- Book ID
- 110088620
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 421 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0271-678X
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π SIMILAR VOLUMES
Axons, the functional elements in CNS white matter, are frequently injured by ischemia, especially in the context of stroke. The pathophysiology of axonal injury induced by energy deprivation has been analyzed in the rat optic nerve and involves excessive calcium influx by way of reverse Na Ο© /Ca 2Ο©
## Abstract We tested the hypothesis that nonβglucose energy sources can support axon function in the rat optic nerve. Axon function was assessed by monitoring the stimulusβevoked compound action potential (CAP). CAP was maintained at full amplitude for 2 hr in 10 mM glucose. 20 mM lactate, 20 mM p