IL10 is an anti-inflammatory cytokine that has been found to have lower production in macrophages and mononuclear cells from asthmatics. Since reduced IL10 levels may influence the severity of asthma phenotypes, we examined IL10 singlenucleotide polymorphisms (SNPs) for association with asthma sever
AVPR1A and OXTR polymorphisms are associated with sexual and reproductive behavioral phenotypes in humans
✍ Scribed by Zoë M. Prichard; Andrew J. Mackinnon; Anthony F. Jorm; Simon Easteal
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 125 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1059-7794
No coin nor oath required. For personal study only.
✦ Synopsis
Communicated by Stephen Chanock
Distinct life history patterns have been observed and characterized in humans and appear to have a heritable component. The specific genetic variation responsible for the heritability is unknown. This study tested two plausible candidate genes for association with human life history characteristics using a sample of Caucasian men and women taken from a large Australian community survey. Associations were found between two polymorphisms within the AVPR1A gene and age of first sexual intercourse in men and women. An association was also found between a polymorphism in the OXTR gene with the tendency to parent children at an earlier age in females. This study is the first to report associations between AVPR1A and OXTR genetic variation with life history traits in humans.
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