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Avoid stavudine plus zidovudine combination therapy?

Book ID
120869248
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
2000
Weight
138 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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Mutations conferring resistance to zidovudine diminish the antiviral effect of stavudine plus didanosine
โœ Izopet, J.; Bicart-See, A.; Pasquier, C.; Sandres, K.; Bonnet, E.; Marchou, B.; ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 91 KB

This study evaluated the influence of zidovudine (ZDV) resistance mutations on the antiviral effect of the combination of stavudine (D4T) plus didanosine (ddI) in patients treated previously with ZDV plus zalcitabine (ddC). Twenty patients who had been treated with ZDV plus ddC for a median duration