๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Avascular necrosis of bone in bone marrow transplant patients

โœ Scribed by Russell, J. A. ;Blahey, W. B. ;Stuart, T. A. ;Edwards, G. ;Card, R. T.

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
326 KB
Volume
17
Category
Article
ISSN
0098-1532

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โœฆ Synopsis

Avascular necrosis of the hips occurred in two patients after allogeneic bone marrow transplantation. One had been receiving steroid therapy for prophylaxis of graftversus-host disease, the other for the treatment of this condition. This complication has been reported infrequently, but the incidence could be as high as 10% in long-term survivors of bone marrow transplantation. While other drugs and irradiation may also contribute to this condition, it is likely that steroids are the major cause. An awareness of this risk should encourage minimizing the use of steroid therapy after bone marrow transplantation.

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## Abstract ## BACKGROUND: Avascular necrosis (AVN) is a debilitating condition reported after chronic steroid use. The purpose of this study was to describe the magnitude of risk in individuals who survived โ‰ฅ1 years after hematopoietic cell transplantation (HCT), and to investigate the role of im