๐”– Bobbio Scriptorium
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Avascular necrosis of bone following combination chemotherapy for acute lymphocytic leukemia

โœ Scribed by Felix, Carolyn ;Blatt, Julie ;Goodman, Mark A. ;Medina, Jocelyn

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
844 KB
Volume
13
Category
Article
ISSN
0098-1532

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โœฆ Synopsis

Avascular necrosis of bone (AVNB) i s a known complication of systemic adrenocorticosteroid therapy, and one which is thought to be dose-related. However, despite the large amounts of prednisone which have been used in the standard treatment of acute lymphocytic leukemia (ALL), AVNB rarely has been reported in children with that disease. We described our experience with one adolescent with ALL who developed multifocal AVNB presenting as bone pain after aggressive chemotherapy that included a high cumulative dose of corticosteroids as well as other antitumor agents, some of which also have been associated with AVNB. Four similar cases from the literature are reviewed. Because the bone pain of AVNB can mimic that of leukemic relapse, this is an important entity to be aware of, and one which may become more common with increasingly aggressive combination chemotherapy.

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