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Availability of Tetrahydrobiopterin Is Not a Factor in the Inability to Detect Nitric Oxide Production by Human Macrophages

✍ Scribed by N. Sakai; S. Milstien


Book ID
115573019
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
358 KB
Volume
193
Category
Article
ISSN
0006-291X

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## Abstract Nitric oxide (NO) from astrocytes is one of the signalers used by the brain's extensive glial‐neuronal‐vascular network, but its excessive production by pro‐inflammatory cytokine‐stimulated glial cells can be cytodestructive. Here, we show how three pro‐inflammatory cytokines (IL‐1β, TN