Degradation of polysorbates 20 and 80: S
โ
Ravuri S. K. Kishore; Astrid Pappenberger; Isabelle Bauer Dauphin; Alfred Ross;
๐
Article
๐
2011
๐
John Wiley and Sons
๐
English
โ 358 KB
The purpose of this work was to study the mechanistic pathways of degradation of polysorbates (PS) 20 and PS80 in parenteral formulations. The fate of PS in typical protein formulations was monitored and analyzed by a variety of methods, including (1)H NMR, high-performance liquid chromatography/eva