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Autosomal dominant Lewy body parkinsonism in a four-generation family

✍ Scribed by Dr. C. H. Waters; C. A. Miller

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 655 KB
Volume: 35
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.410350110

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✦ Synopsis

We report a family with autosomal dominant parkinsonism. The propositus developed parkinsonism at a relatively young age (45 years) and came to autopsy after a 6-year illness. She had typical features of Pdrkinson'S disease except for an absence of rest tremor, although this was present i n other family members. A diagnosis of Lewy body parkinsonism was confirmed by neuropathological examination. Additional pathological features included the presence of cortical Lewy bodies and anti-ubiquitin-positive neurites in the cornu Ammonis 2 and 3 (CA2-3) region of the hippocampus. This kindred is similar both clinically and pathologically to a few previously reported pedigrees, further strengthening recent evidence of a genetic etiology of some forms of Parkinson's disease.

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