✦ LIBER ✦
Autoreactivity versus autoaggression: a different perspective on human autoantigens
✍ Scribed by Sarah L Parry; Frances C Hall; Jennifer Olson; Thomas Kamradt; Grete Sønderstrup
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 529 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0952-7915
No coin nor oath required. For personal study only.
✦ Synopsis
Antigen-specific B and T cell responses against myelin basic protein, as well as responses against beta-islet-cells or joint tissue, are commonly found both in patients with autoimmune disease and in normal control subjects with disease-associated HLA-DR/DQ alleles. Thus, autoreactive immune responses are not disease-specific; however, the presence of certain autoantibodies may have prognostic value and may aid in disease management.