Binding of Clozapine Metabolites and Ana
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Alexandra Alves-Rodrigues; Rob Leurs; Edwin Willems; Henk Timmerman
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Article
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1996
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John Wiley and Sons
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English
โ 439 KB
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Following up h e finQng that the non-imidazole drug clozapine shows a considerable histamine H3 receptor antagonistic activiryl 1.21 , a scrim of analogues and metabolites (clorapinc-N-oxide. and N-desmcthylclozapine) were tested for thcir affinity towards thc H3 receptor using the radiolabelled H,